The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review
نویسندگان
چکیده
منابع مشابه
The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review
Epidemiological studies and mouse models suggest that maternal immune activation, induced clinically through prenatal exposure to one of several infectious diseases, is a risk factor in the development of schizophrenia. This is supported by the strong genetic association established by genome wide association studies (GWAS) between the human leukocyte antigen (HLA) locus and schizophrenia. HLA ...
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متن کاملThe Major Histocompatibility Complex: a Review
One of the important components of the immune system, the major histocompatibility complex (MHC) molecules allow T-lymphocytes to detect cells, such as macrophages, B-lymphocytes, and dendritic cells that ingest infectious microorganisms or the self-cells infected with microorganism. On being engulfed a microorganism, macrophage partially digests it and displays peptide fragments of the microbe...
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Genome-wide association studies (GWAS) in schizophrenia have focused on additive allelic effects to identify disease risk loci. In order to examine potential recessive effects, we applied a novel approach to identify regions of excess homozygosity in an ethnically homogenous cohort: 904 schizophrenia cases and 1640 controls drawn from the Ashkenazi Jewish (AJ) population. Genome-wide examinatio...
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ژورنال
عنوان ژورنال: Journal of Clinical & Cellular Immunology
سال: 2016
ISSN: 2155-9899
DOI: 10.4172/2155-9899.1000479